Endocrine Abstracts

Background: Agranulocytosis is rare and may develop in 0.2–0.5% patients using antithyroid drug therapy (ATD). We report on a patient who developed febrile neutropenia two weeks after starting treatment with methimazole.Case Report: A 74-year-old female, with no relevant medical history, was diagnosed with Graves disease and treated with methimazole (30 mg/day). Three weeks after starting therapy she presented to the emergency department with compla...

Dysregulation of types 2 and 3 deiodinases (D2 and D3) alters the metabolism of thyroid hormones in the patients with nonthyroidal illness syndrome (NTIS). Previous studies have demonstrated that deiodinase expression varies in the muscle in different disease models. Nevertheless, the location of D2 and D3 and the effect of oxidative stress on reticulum endoplasmic (ER) and mitochondrial function are not described in human muscle with different types of acute disease and NTIS....

Dysregulation of types 2 and 3 deiodinases (D2 and D3) are present and profoundly alters the metabolism of thyroid hormones in the nonthyroidal iIllness syndrome (NTIS). The activation of this enzyme in peripheral blood cells can be one of the factors that alters the progression of this syndrome. However, the effect of oxidative stress on D3 expression in these cells from ill patients is unknown.ObjectiveEvaluate the presence and variations of D3 expression in the granulocytes...

Objectives: Assess the efficacy and safety of ultrasound-guided percutaneous ethanol injection (PEI) for treating benign cystic or predominantly cystic-thyroid nodules (TN).Methods: Retrospective analysis of all euthyroid patients treated with PEI for purely (>90% of cystic component) or predominantly cystic (50%-90% of cystic component) TN between January 2018 to February 2023. Efficacy was defined as 50% or greater reduction in pretreatment volume ...

The RET receptor tyrosine kinase is an established oncogenic driver in multiple cancers. Activating RET point mutations give rise to the cancer syndrome Multiple Endocrine Neoplasia type 2 (MEN2), characterized by medullary thyroid carcinoma and pheochromocytoma. Correlations of specific RET mutations with MEN2 disease phenotypes and severity have been well documented, however the molecular mechanisms that distinguish the functions, locations, and protein interactions of speci...

Introduction: Differentiated thyroid cancer (DTC) is rare in the paediatric population when compared to adults. Paediatric patients often present with advanced disease at diagnosis, characterized by multifocal disease, heightened lymph node involvement, and distant metastasis. Additionally, they face a higher risk of post-operative complications in comparison to adults. Despite that, paediatric DTC exhibits an excellent prognosis.Methods: A retrospective...

Adrenocortical carcinomas (ACC) are rare and usually very aggressive tumors with heterogeneous outcomes. The individual variability in tumor progression and patients’ survival is linked to ACC biology and molecular heterogeneity, reinforcing the need to identify markers with prognosis value, to allow an accurate clinical strategy. Currently, in the absence of specific molecular markers, ACC prognosis is mainly predicted by the European Network for the Study of Adrenal Tum...

Most of adrenocortical tumors (ACT) are benign and non-functioning tumors, in contrast to adrenocortical carcinomas (ACC), which are rare and usually very aggressive tumors with a poor prognosis. The pathological discrimination between adrenocortical adenomas (ACA) and ACC is mainly based on unspecific and subjective histological features, resulting in inaccurate diagnosis in several cases. Numerous studies have previously described the potential value of immunohistochemistry ...

Introduction: Adrenocortical carcinoma is a rare type of cancer that usually has a dismal prognosis. The concurrent hormonal excess of some of these tumours can have an additional negative impact on patients´ morbidity and mortality.Clinical Case: We present the case of a 57-year-old woman diagnosed with stage IV adrenocortical carcinoma, with liver and bone metastasis, and associated ACTH-independent Cushing syndrome and hyperandrogenism. The patie...

Introduction: Pancreatic neuroendocrine tumors (PNETs) originate from neuroendocrine islet cells and can therefore secrete several neuropeptides. Multiple and secondary hormone secretion have been described in a minority of cases, mostly with advanced disease, and it has been hypothesized that this complex secretion pattern can serve as a marker for tumor behavior.Case report: Male patient, 69 years old, diagnosed with a glucagonoma with pulmonary and he...